teo123 wrote: ↑Tue Apr 27, 2021 11:41 am
A related question: why don't viruses that jump from one specie to a distantly related one die out from inbreeding after a few generations?
1. Viruses don't work like multicellular organisms. As I explained before, they have far less genetic information and have far more progeny, which means among those there are many many many perfect clones. That means effectively no harmful genetic degradation from generation to generation. They do not *need* new genetic information. If one was effective then so will be its clones, of which it will produce many perfect copies.
teo123 wrote: ↑Tue Apr 27, 2021 11:41 amViruses co-evolve with the hosts, right?
2. They need to keep up with the host's immune system, but it takes a long time for a species to evolve to make the virus obsolete. Immunological adaptation is principally within an individual via acquired immunity. As long as there are new individuals being born who can be infected (do not have full immunity) the virus can survive for a very very long time with only clones and no new genetic information.
teo123 wrote: ↑Tue Apr 27, 2021 11:41 am
And virus equivalent of sexual reproduction is when two viruses infect the same cell, right? So, when a bat coronavirus receives a mutation that enables it to attack humans... it essentially enters an eco-system in which there is no organism of its specie. The coronavirus that lives in humans which is most closely related to COVID-19 is separated from COVID-19 by tens of millions of years, and "mating" with it will not produce viable offspring.
3. No. First, millions of years to a virus is nothing when they take information across individuals separated by over a billion. Viruses are very simple and they function very similarly. Second, your assumptions of millions of years of separation is false. Viruses diffuse across species much more frequently than you assume and the gene pool is very wide. Third, viruses don't even need other individuals of their respective types to get new genetic information, they can take it from the host cells, as well as other viruses of totally different types infecting the same cells. Finally, because of their simplicity and how many individuals are involved errors themselves are also far more likely to result in beneficial mutations so they don't even need to take genetic information from anywhere else.
teo123 wrote: ↑Tue Apr 27, 2021 11:41 amSo, one would expect COVID-19 to disappear due to inbreeding in a few generations, as the harmful genetic mutations in it accumulate.
I already explained to you in another thread why this was wrong. How do you expect me to answer your questions when you're disrespectful enough of my time to forget those answers in a matter of months?
teo123 wrote: ↑Tue Apr 27, 2021 11:41 amWhere is the error in that reasoning?
Your error is trying to reason about something empirical. It can be done by some, but clearly not by you. It leads you to incorrect beliefs 99% of the time -- like that the Earth is flat, bombs and airplanes don't exist, and prisons don't exist. Some of these things you apparently still even believe.
Stop trying to use reason to arrive at empirical conclusions. Instead, pick up a book on virology if you're curious about these things. Clearly experts do not believe your conclusion to be the case, so you should assume you are wrong and that you fundamentally misunderstand virology. Start with 101 and stop trying to jump ahead when you don't understand the first thing about viral evolution or replication.